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	Provedor de dados BJMBR (4) Autor Borges,F.T. (4) Schor,N. (4) Pessoa,E.A. (2) Caires,A. (1) Castino,B. (1) Convento,M.B. (1) Dalboni,M.A. (1) Fernandes,G.S. (1) Fernandes,S.M. (1) Fonseca,C.D. (1) Leme,A.M. (1) Michelacci,Y.M. (1) Oliveira,A.S. (1) Reis,L.A. (1) Silva,R.G. (1) Vattimo,M.F. (1) Mais... Palavra-chave Acute kidney injury (2) Apoptosis (2) Bosentan (1) Cell biology (1) Cyclosporine-A (1) Diagnosis (1) Endothelin-1 (1) Extracellular vesicles (1) Genetically hypertensive rats (1) Gentamicin (1) Glycosaminoglycan (1) Kidney diseases (1) LLC-PK1 cells (1) Lipopolysaccharide (1) MDCK (1) Macitentan (1) Nitric oxide (1) Noncrystalline uric acid (1) Pre-conditioning (1) Proteoglycan (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2018 (1) 2013 (1) 2010 (1) 2009 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats BJMBR Caires,A.; Fernandes,G.S.; Leme,A.M.; Castino,B.; Pessoa,E.A.; Fernandes,S.M.; Fonseca,C.D.; Vattimo,M.F.; Schor,N.; Borges,F.T.. Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to evaluate the effect of Endothelin-1 (ET-1) receptor blockade with bosentan (BOS) and macitentan (MAC) antagonists on altered renal function induced by CsA in normotensive and hypertensive animals. Wistar and genetically hypertensive rats (SHR) were separated into control group, CsA group that received intraperitoneal injections of CsA (40 mg/kg) for 15 days, CsA+BOS and CsA+MAC that received CsA and BOS (5 mg/kg) or MAC (25 mg/kg) by gavage for 15 days. Plasma... Tipo: Info:eu-repo/semantics/article Palavras-chave: Genetically hypertensive rats; Acute kidney injury; Cyclosporine-A; Bosentan; Macitentan; Endothelin-1. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200611 Extracellular vesicles: structure, function, and potential clinical uses in renal diseases BJMBR Borges,F.T.; Reis,L.A.; Schor,N.. Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Extracellular vesicles; Cell biology; Kidney diseases; Diagnosis; Treatment. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000824 Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein BJMBR Pessoa,E.A.; Convento,M.B.; Silva,R.G.; Oliveira,A.S.; Borges,F.T.; Schor,N.. Nephrotoxicity is the main side effect of antibiotics such as gentamicin. Preconditioning has been reported to protect against injuries as ischemia/reperfusion. The objective of the present study was to determine the effect of preconditioning with gentamicin on LLC-PK1 cells. Preconditioning was induced in LLC-PK1 cells by 24-h exposure to 2.0 mM gentamicin (G/IU). After 4 or 15 days of preconditioning, cells were again exposed to gentamicin (2.0 mM) and compared to untreated control or G/IU cells. Necrosis and apoptosis were assessed by acridine orange and HOESCHT 33346. Nitric oxide (NO) and endothelin-1 were assessed by the Griess method and available kit. Heat shock proteins were analyzed by Western blotting. After 15 days of preconditioning, LLC-PK1... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pre-conditioning; Gentamicin; Nitric oxide; LLC-PK1 cells; Acute kidney injury; Apoptosis. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000700005 Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK) BJMBR Borges,F.T.; Dalboni,M.A.; Michelacci,Y.M.; Schor,N.. Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals. We analyzed the effect of noncrystalline UrAc on GAG synthesis in tubular distal cells. MDCK (Madin-Darby canine kidney) cells were exposed to noncrystalline UrAc (80 µg/mL) for 24 h. GAGs were labeled metabolically and characterized by agarose gel electrophoresis. The expression of proteoglycans and cyclooxygenase 2 (COX-2) was assessed by real-time PCR. Necrosis, apoptosis and prostaglandin E2 (PGE2) were determined by acridine orange, HOESCHT 33346, and ELISA, respectively. CaOx crystal endocytosis was evaluated by flow cytometry.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Noncrystalline uric acid; Glycosaminoglycan; MDCK; Lipopolysaccharide; Apoptosis; Proteoglycan. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000006 Registros recuperados: 4 Primeira ... 1 ... Última

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